Research-based teaching is an efficient teaching method to cultivate and improve the creative ability of students. Based on problems in teaching Advanced Organic Chemisty, this paper put forward the idea of research-based teaching and the ways to reform teaching methods. In the practice of teaching, it is strongly suggested that teachers should play the leading role in teaching process and graduates should be in predominant position. All kinds of teaching methods such as students’ participating, discussing, symposium should be conducted so as to guide the students to exploratory study . At the same time, creative education is developed in the practice of research-based teaching.