Abstract:Gene editing technique, a kind of gene engineering technique making gene positioning and accurate modifying come true, has been widely used in fields of agriculture, medicine and environmental protection. However, the risk and uncertainty come with the advent of gene editing technology, which originates from the offtarget effects and ethical dispute in applications, especially for clinical practice and agricultural breeding and presents in a manner of diverse interests. After a comparative study of laws and regulations of gene editing technique in US and Europe, this paper finds that there is a close relationship between the practice effect of risk management and legislation pattern, administrative means and legal system. As for China, current laws and regulations, together with the traditional legal theory, are far from adequate to regulate the technology and its potential risk. Therefore, there is a necessity to compile specialized laws on biotechnology based on its personal traits and the governance needs of products, improve the riskpreventing system and ethic censorship, better the ongoing biotechnology supervision system and reinforce the procedural right so as to systematically respond to the risk management issues in the application of gene editing technique.