Abstract:The dissemination of scientific issues has become more complex due to the advent of various new media in “post-normal” era. User-generated content provides scientists and science advocates with more ways to work on science popularizations,and meanwhile greatly facilitates the public to participate in the social debates of scientific issues,thus providing ample research materials for learning the Game Theory and tension between the sending and the receiving. The landscape of science communication has profoundly changed. And the dislocation of the sending and the receiving is of vital importance to the effective dissemination of scientific issues. This study took one GMO-themed speech article published in two social media platforms as the case to investigate the tension between scientific communicators and their assumed target audience. The content analysis revealed the overlap and dislocation between transmission and reception of the speech manuscript from two levels,theme and interpretation. It was found that at the theme level,there was a large overlap between the speech manuscript and comments,with only two exceptions,namely,“ethics and morality” and “expression of opinions through opinion leaders”. However,at the level of interpretation,there was a big difference. Although both sides agreed upon the uncertainty of science and technology,they expressed their views in quite opposite ways. In addition,trust in government regulations varied. And there was a dislocation in the interpretation of GM in terms of its social impacts and significance to scientific popularization. There was also suspect about the legitimacy of the science popularizers.