The development of human society has been entering an era of uncertainty nowadays, and the recurring outbreaks of COVID-19 since the end of 2019 have made the uncertainty of social development more pronounced. This paper takes three uncertainties in the Covid governance in Shanghai in 2022 as an example to analyze the characteristics beyond common perception. It is argued that the existing mindset of “seeking stability” must be changed in the era of uncertainty and the thinking mode of resilient governance, differentiation, autonomy, and multi-line development concept must be established. At the same time, emergency strategies and mechanisms must be adapted to the changing circumstances in order to face the challenges in the volatile future.