Generally,establishing the development strategy of a medium-or small-size technological enterprise is always a problem that every enterprise must face.The reason for the importance is that it represents the enterprise's core competence on market participation.It needs to carry out prosecution selection from many aspects such as human resource,financing,management,technology,production and sale,system,structure,culture,etc.As the college-run medium-or small-size technological enterprises' developments depend on the college's growth environment,the enterprises' connotation covers more content and their congenital advantages and acquired defect are obvious,which should be paid more attention to.This paper analyses the specific points and difficulties of college-run medium-or small-size technological enterprises development strategies and discusses the college growth environment characteristics and then puts forward some suggestions about college run medium-or small-size technological enterprises strategy selection.