Cooperation of Chamber of Commerce among Guangdong,Hong Kong and Macao is an integral part of the entire Pearl River Delta regional cooperation,which is very important to coordinate the interests of the above three places as well as to promote regional economic and social development.However, barriers of structure,mechanism and related systems restrict the development of the civil chamber of commerce in these three places as "community line ".Based on the current situation of the cooperation and the actual needs of private businessmen,this paper put forward some suggestions on how to push forward the cooperation of chamber of commerce in Guangdong,Hongkong and Macao.These suggestions include establishing joint meeting system,regularly holding forum on cooperation of chamber of commerce in these three places,establishing the track mechanism of forum achievements and forming broader system of association cooperation and negotiation.