Nowdays, there exists potential security risk in production, processing, circulation and marketing of agricultural products. In addition, safety of agricultural product has not strictly enforced, which leads to frequent accidents of agricultural product safety and serious harm to consumers’ health and life. Based on the analysis on the significance of carrying out integrative manangement of agricultural product safety of city and countryside, this paper puts forward the integrative management framework of agricultural product safety and proposes several specific measures on how to strengthen integrative manangement of agricultural product safety of city and countryside from organizational mode, talent cultivation and institutional management.