Litchi is very popular and import fruit in South China. Under the household survey data, this paper explores the relationship between the economic scale and production efficiency. From the description analyses, we found that as the increasing of acreage of litchi farm, the average input decrease very fast. With the Stochastic Frontier Models, the economic return to the scale is not exist for the production output, but is exist for the value output. For specific farm, the production efficient level is related to the scale of output, the farmer can gain high economic return from enlarges the farm size. Encourage the development of family farm with an appropriate operation scale and the specialized farmers’ cooperatives organization.