The prescriptions of traditional Chinese medicine （TCM） compound related to the treatment of piglet diarrhea were collected from CNKI，WanfangData，VP Database and ancient books，and the medication pattern of medication frequency，medicinal properties，medicinal flavors，categorization，medicinal pairs，and association rules was analyzed with Python and SPSS to mine data to study the medication pattern and mechanism of TCM in the treatment of piglet diarrhea.The core pairs of drugs were analyzed with cyber-pharmacology.The components and targets were extracted with TCMSP database and Swiss ADME platform.The intersection targets were analyzed by protein interaction analysis with STRING database.The mediators of targets were obtained with Network Analyze of Cytoscape 3.9.1 software.The GO and KEGG enrichment of the targets were analyzed with webgestalt database.The results showed that there were 19 medicines with a frequency of ≥5 used in TCM for the treatment of piglet diarrhea，among which the medicine with high-frequency was Poria cocos，Coptis chinensis，Atractylodes macrocephala，Codonopsis pilosula，Tangerine peel and Astragalus membranaceus. 38.13% medicines are warm medicinal properties.33.21% and 33.03% medicines are mainly sweet and bitter medicinal flavor，with the spleen （22.94%），stomach （18.07%），and lungs （13.67%） being the main meridians.The drug pairs with high-frequency are Codonopsis pilosulae， Atractylodes macrocephala and Poria cocos，with the frequency of more than 10 times，and the combination is closely associated.A combination involving 22 active ingredients and 672 targets was obtained with screening and deduplication.The results of GO analysis showed that 12 targets related to biological processes，21 targets related to cellular components，and 18 targets related to molecular functions，involving 10 KEGG pathways.It is indicated that most of the drugs used in the treatment of piglet diarrhea are heat-clearing，food-eliminating and tonic drugs，and the core pairs of medicine are represented by Codonopsis pilosulae， Atractylodes macrocephala and Poria cocos，with active ingredients acting on the inflammation-related targets including ALB，AKT1 and TP53，and participating in the pathways of MAPK，Ras and cAMP to exert the antidiarrheal effect.