The water quality of Honghu Lake between 2007 and 2010 was taken as an example and the geostatistics and five commonly used interpolation methods (radial basis function,inverse distance weighted,global polynomial,local polynomial and ordinary Kriging) were used to analyze the temporal and spatial conditions of water quality of Honghu Lake.Error evaluation factors (MAE,MRE and RMSE) were employed to evaluate the fitting situation.It concluded that all factors of the water quality had high spatial-temporal heterogeneity and the concentration of total nitrogen was influenced by temperature,water depth and water cycle.Among the five kinds of interpolation methods,the radial basis function had a better predict result.The total nitrogen concentration of Honghu Lake had different characteristics of spatial distribution.