Trim63(tripartite motif containing 63),also known as muscle RING finger protein 1 (MuRF1),plays an important role in the development and differentiation of the muscles in mammals.Partial cDNA sequence of the Misgurnus anguillicaudatus trim63a gene (Matrim63a) was cloned in this study.Sequence analysis showed that the fulllength Matrim63a CDs was 1 035 bp,encoding 344 amino acids,which shared high similarity with those of other teleosts.The Matrim63a mRNA expression in different tissues of the adults and during embryonic developmental stages in the diploid and tetraploid M. anguillicaudatus were examined by qPCR. Matrim63a showed highest expression in the muscle and followed by the heart.During embryonic development,Matrim63a was examined in all the 13 stages with different expression levels.