The field plot experiments were conducted to apply organic fertilizer to vegetables including cabbage， radish， pepper for three consecutive seasons and citrus （Majia pomelo） for many years to compare the effects of applying organic fertilizer instead of chemical fertilizer on the yield， quality of fruits and vegetables and the content of heavy metals in soil. Using no fertilization （CK） and fertilizer application （CF） as the control， two organic fertilizer treatments with equal nitrogen fertilizer application including OF1， OF2 were set up. The results showed that both OF1 and OF2 treatments ensured that the yield of vegetables in the first two seasons and Majia pomelo do not decrease， and significantly increase the contents of soluble solids in Majia pomelo and the content of organic matter in vegetable soil compared with CF treatment. There was no significant difference in the content of heavy metals between vegetables under different treatments in the first two seasons， but the content of Pb in the edible part of radish treated with OF1 and OF2 was close to the limit standard. In the vegetables of third season， the contents of Cr， As， Cu and Zn in edible parts of pepper treated with OF1 and OF2 were significantly higher than those treated with CF. The content of Pb in the pulp and peel of Majia pomelo fruit treated with OF1 exceeded the limit standard， and that with OF2 treatment was close to the limit standard. The content of various heavy metals in vegetable soil was far lower than the value of risk control， but the content of Pb， Cd， Hg had significantly accumulated compared with CF treatment， among which the content of Hg was the fastest. It is indicated that the application of two organic fertilizer with equal nitrogen fertilizer can increase the yield and quality of fruits and vegetables， improve the physical and chemical properties of soil in a short time， but increase the accumulation of heavy metals in soil as well. Therefore， continuous application of organic fertilizer will lead to the risk that the content of heavy metals in fruits and vegetables exceeds the limit standard.