Two kinds of deactivators including biochar and sepiolite were used to study the deactivation effects of different compound ratios （mass ratios of 1∶1，1∶2，2∶1），application amount （1% and 3%） and deactivation time （45 d and 90 d） on the content of Cd and Zn in contaminated soil to restore the cadmium （Cd） and zinc （Zn） co-contaminated soil around a landfill in Sichuan. The effects of compound deactivators on the availability and speciation distribution of Cd and Zn in contaminated soil were analyzed. The changes of stability and mobility of Cd and Zn in soil were investigated with the stability index （I_R value） and mobility index （M_F value）. The results showed that the deactivation effect of Cd and Zn in soil significantly increased with the increase of deactivation time and application amount. The deactivation effect of Cd and Zn in soil was the best when the ratio of biochar to sepiolite was 2∶1，and the deactivation rate was 31.1% and 23.1%，respectively. After the application of compound deactivators，the proportion of weak acid extractable and reducible fractions of Cd and Zn in soil decreased while the proportion of oxidizable and residual fractions increased. The application of compound deactivators enhanced the stability and decreased the mobility of Cd and Zn in soil compared with the control. When the ratio of biochar to sepiolite was 2∶1，the M_F value of Cd in soil decreased by 17.5% and the I_R value increased by 9.0%. The M_F value of Zn in soil decreased by 6.1% and the I_R value increased by 18.7% at 3% application amount. In general，biochar and sepiolite mixed at a mass ratio of 2∶1 and a dosage of 3% had the best remediation effect on the content of Cd and Zn in the co-contaminated soil.