The observation data of the initial flowering period of Japanese cherry trees in the cherry blossom garden at Wuhan University and the meteorological data of the same period were used to analyze the temporal and spatial response characteristics of the flowering period of cherry blossoms to the urban heat island effect in Wuhan to improve the accuracy of the model for predicting the flowering period of cherry blossom in Wuhan and to better predict the flowering period of cherry blossom. The results showed that the urban heat island effect in Wuhan has been significantly enhanced since the late 1980s. The warming rate and contribution rate of urban heat island in winter have increased significantly since 1988. The urban heat island effect was the highest in the central urban areas of Wuhan， spreading and radiating from the urban core areas to the suburban areas. Huangpi and Xinzhou in the northern areas of Wuhan City were almost unaffected by the heat island effect. The flowering period of cherry blossom in Wuhan had obvious temporal and spatial response to the urban heat island effect in winter. The 5-year sliding average UHII of average winter temperature increased by 1 ℃， leading to an early flowering period of cherry blossoms by about 2.8 days. The Hankou River Beach， Holiday Inn Riverside and other places in the central urban areas of Wuhan were the first places where cherry blossoms bloomed， 1?2 days earlier than the flowering period of Wuhan University. The flowering period of cherry blossom garden in East Lake and Dijiao Park was 1?2 days later than that of Wuhan University. It is indicated that the urban heat island effect significantly advances the flowering period of cherry blossoms in Wuhan， and the flowering period of in the areas with strong urban heat island effect was earlier than that in the areas with weak urban heat island effect.