640 piglets with diarrhea were sampled and statistically analyzed to study the genetic factors and pathways for anti-diarrhea in suckling piglets.600 samples including 453 large white pigs，105 landrace pigs and 42 Duroc pigs were selected for the low depth resequencing （1×）.Genome-wide association study（GWAS） was conducted after the quality control of the results of sequencing.42 and 107 significant SNPs were screened in large white pigs and landrace and pigs，respectively，with 32 and 82 genes involved at the upstream and downstream 20 kb regions of these loci.GO and KEGG enrichment analysis was performed on these genes.The results showed that 6 important candidate genes including PLA2G4A，C1RL，PTPN6，C1R，PPP1R12A，and GRID2 and 8 important candidate genes including DAPK1，TMC8，ITM2C，CHMP4B，CAST，PDE4D，HSPA4，and GRID2 that may be associated with diarrhea traits in suckling piglets were identified，with GRID2 being screened simultaneously in both large white pigs and landrace pigs.It is indicated that candidate genes for diarrhea in piglets are associated with functions related to cell apoptosis，immunity，cell barrier，and transmembrane transport of substances.